DNA Maternal Ancestry Test
Fee Schedule for Year 2019
|Test Type||Private Test Kit|
|Standard Maternal Ancestry Package (mtDNA HVR1 Test)||$962Order Kit|
|Advanced Maternal Ancestry Package (mtDNA HVR1 + HVR2 Test)||$1528Order Kit|
|Premium Maternal Ancestry Package (mtDNA HVR1 + HVR2 + Coding Region Test)||$4269Order Kit|
All orders received before 2pm are shipped out the same business day. All orders received after 2pm or on weekends or holidays are shipped out the following business day. 24/7 online status check and account management available for all tests.
What is mtDNA?
Mitochondrial DNA (mtDNA) is found in the mitochondria of human cells. Each cell can contain several mitochondria, and each mitochondrion contains dozens of copies of mtDNA. So in every cell there can be thousands of copies of mtDNA. This is different from nuclear DNA, since we only inherit two copies of the autosomal and sex chromosomes per cell.
mtDNA is passed down strictly from mother to child along the direct maternal line. The matrilineal inheritance pattern of mtDNA means that all people who descended from the same matrilineal ancestral lineage will have exactly the same mtDNA profile. mtDNA testing allows you to trace the ancestry of your direct maternal lineage (your mother’s, mother’s, mother’s… maternal lineage).
Using your mtDNA results, you can find out whether you are linked to any other individual along your direct maternal line; you can search a global database to seek potential long lost maternal line relatives from around the world; and you can find out your ancient mtDNA Haplogroup.
Both males and females have mtDNA so both males and females can take the mtDNA test.
What is mtDNA sequencing?
The circular mitochondrial genome has three regions – two small hypervariable (HVR) regions and a large coding region. It is possible to sequence just the HVR1 region, both hypervariable regions (HVR1 and HVR2), or the complete mitochondrial genome (HVR1, HVR2 and the coding region).
The hypervariable regions comprise approximately 1100 bases of the mtDNA genome. Most of the variation in the mtDNA occurs in these regions. If two people have a perfect match at their HVR1 and HVR2 regions, further analysis of the much larger coding region can provide a higher stringency comparison and further resolution. The coding region covers the remainder of the mitochondrial genome and the complete mitochondrial genome is 16,569 base pairs.
What do you get when you order a Maternal Ancestry (mtDNA) test?
You will receive a certificate with the genetic sequence of mtDNA region(s) that you have tested and your predicted or confirmed mtDNA Haplogroup. You will also be able to access the following complimentary databases to bring your ancestry to the next level
- DNA Reunion database - search for long lost relatives on your direct paternal line
- Indigenous DNA database - find out which indigenous population is the closest match to your paternal lineage
- DNA Haplogroups database - trace the ancient migration of your paternal ancestors to their final ancestral homeland
- Famous DNA database - compare your DNA against famous historical figures
What is the significance of mtDNA HVR1, HVR2 and Coding Region sequences?
mtDNA is unique because it is passed down strictly along the direct maternal line (from mother to child). Only females can pass their mtDNA down to their children, so even though both males and females have mtDNA, only females can pass their mtDNA down to the next generation.
The maternal line inheritance pattern of mtDNA means that your mtDNA is inherited directly from your matrilineal ancestors (mother’s, mother’s, mother’s…. maternal lineage). The matrilineal inheritance pattern of mtDNA means that all people who have descended from the same maternal lineage as you will have exactly the same mtDNA as you.
What can I do with my mtDNA Sequencing results?
Using your mtDNA sequencing results, any two individuals can compare their profiles to see whether they descended from the same maternal line. If the mtDNA test shows that two individuals have different mtDNA profiles, it would conclusively prove that they did not descend from the same maternal lineage.
You can use your mtDNA profile to compare with other individuals in your tree to confirm a positive linkage, verify new linkages, or verify findings from your paper research.
You can also use your mtDNA markers to search our global database to find potential matches from around the world. You can even choose to receive automatic notifications by email whenever a new match is found.
What is the difference between testing only the HVR1 region versus testing both HVR1 and HVR2, or testing the full mtDNA (HVR1, HVR2 and Coding Region)?
The mtDNA consists of 3 regions: HVR1, HVR2 and Coding Region. The more mtDNA regions you test, the more stringent your comparisons will be when matching against another individual.
For example, a perfect match with another individual at all 3 regions will be a far stronger match than a match at only the HVR1 region. If you have a HVR1 match with another individual, comparing more regions will provide further clarification of the relevance of the match and will allow you to see if you continue to match when more regions are compared.
If you test only your HVR1 and HVR2 regions, the top 5 most likely mtDNA haplogroups that you belong to will be predicted. If you take the mtDNA full sequencing test (test all 3 regions of the mtDNA: HVR1, HVR2 and Coding Region), your mtDNA haplogroup and subclade will be confirmed.
If I test only the HVR1 region, can I test more regions at a later date?
In total the mtDNA has 3 regions: HVR1, HVR2 and Coding Region. If you test only the HVR1 region, or only the HVR1 and HVR2 Regions, you can choose to test the remaining region(s) at a later date. However, you may be required to collect a new sample for the additional testing.