DNA Skin Health Test
Fee Schedule for Year 2021
|Test Type||Testing Time||Fee|
|DNA Skin Health Test||2 to 4 weeks||$5280Order Kit|
All orders received before 2pm are shipped out the same business day. All orders received after 2pm or on weekends or holidays are shipped out the following business day. 24/7 online status check and account management available for all tests.
The appearance of your skin is an excellent indicator of your overall health. Nutritional deficiencies can cause pale, sallow skin, specific irritants or foods can cause an inflammatory response, and too much sun exposure leads to increased wrinkles and age spots. Other changes, like cellulite and stretch marks, are not physically harmful, but can have a psychological impact on some people.
This DNA test identifies genetic variants that influence your skin health and appearance. While you cannot change your genes, there are various other approaches you can take to help the apperance of your skin.
The skin health industry is a rapidly growing industry and targeted treatments are continuously being developed. Knowledge of your unique genetic variation allows you to choose currently available and future treatments best suited for your skin.
Genetic variants examined in this DNA test looks at the following characteristics involving your skin
- Cellulite – skin dimpling due to an alteration of the skin & fat tissue
- Stretch marks – pale lines due to tearing of the dermis layer of skin
- Varicose veins – enlarged & twisted veins due to faulty leaflet valves & the pooling of blood
- Eczema – common inflammatory skin disorder characterized by itchiness & a rash
- Ichthyosis vulgaris – dry skin condition characterized by thick dry scales
- Psoriasis – inflammatory skin condition characterized by itchy, scaly patches
- Rosacea – inflammatory skin condition characterized by dilated blood vessels on the face
- Glycation – chemical bonding of sugar leading to impaired protein function & skin aging
- Oxidation – process resulting in harmful free radicals that damage our skin
- Wrinkles – creases, folds & ridges that appear as people age
- Freckles – hyperpigmented spots that are clearly visible on fair skin
- Age spots – dark skin areas due to sun exposure & overproduction of melanin
- Tanning – darkening of skin in response to UV radiation
Below we describe in detail a few of the characteristic features and the associated genetic variants that are included in the DNA skin health test.
Freckles (or ephelides) and age spots (or sun spots) are hyperpigmented areas of skin that are clearly visible on people with fair complexion. These darker spots are due to sunlight triggering clusters of cells to overproduce the melanin pigment. Although freckles and age spots are harmless, people who develop them are more susceptible to the harmful effects of UV radiation.
Tanning refers to the darkening of skin in response to UV radiation from sunlight or artificial sources (e.g. tanning beds). UVA radiation oxidises existing melanin, leading to rapid skin darkening, but little protection against sunburn and only a short-term tan. UVB radiation results in delayed tanning (2 to 3 days after exposure), but an increased production of melanin and a tan that lasts for several weeks or months. UVB radiation provides some protection against skin damage and sunburn. People have difficulty tanning are at the highest risk of health complications.
Cellulite and stretch marks
Cellulite and stretch marks are two very common skin changes (particularly in females) that do not cause any physical health problems. However, they can lead to feelings of anxiety, despair and even loathe. Both of these skin changes are influenced by genetic variation.
Cellulite is an alteration of the skin and underlaying fat tissue that results in skin dimpling on the thighs, buttocks and abdomen of over 85% of post-pubertal females, but rarely occurs in males.
Stretch marks affect over 50% of women, but only approximately 25% of men. They are caused by tearing of the dermis layer of skin and are often associated with growth spurts, rapid weight change, longterm steroid use and pregnancy.
Eczema, rosacea and psoriasis are inflammatory skin conditions influenced by genetic variation and other environmental triggers. There is a strong genetic component to eczema with the strongest association to variants in the FLG gene, which encodes an important binding protein in the outermost skin cells.
The symptoms of rosacea include redness, swelling, pimples and dilated blood vessels on the nose, cheeks, chin and forehead. Sunlight, heat, alcohol, exercise, stress, spicy food, menopause and skin bacteria are all thought to be triggers of intense flushing, but the underlying causes of rosacea are unknown.
Psoriasis is a long-lasting autoimmune disease and can range from mild forms with localized affected areas, (commonly the forearms, scalp or navel area), to severe forms where the whole body is affected by red, itchy and scaly skin patches. There is an underlying genetic component to psoriasis, and it can also be triggered by medications, foods, infections or psychological stress.
Varicose veins are enlarged and twisted veins that predominantly occur in the lower legs.They occur due to faulty leaflet valves that don't fully close, allowing blood to flow backwards and accumulate, causing the affected vein to enlarge.
Varicose veins are most common in females over 50 years of age. There is a hereditary component to varicose veins, particularly inheritance of variants in the MTHFR gene. Other contributing factors include pregnancy, obesity, menopause, prolonged standing and leg injury.
Wrinkles and thin, loose skin are all signs of aging skin and there are multiple factors that contribute to these skin changes. Our bodies have developed ways to protect against the reactions that contribute to skin aging, but genetic variations influence how efficient these protective mechanisms are.
Glycation is a reaction that impairs the functions of proteins throughout our bodies, particularly two abundant skin proteins - collagen and elastin - altering the flexibility and elasticity of our skin. Glycation protection refers to the body's methods of removing these harmful glycation products, but people who carry a genetic variant in the GLO1 gene are not protected as well, leading to increased skin aging.
Oxidation is another ongoing reaction in our bodies, leading to the formation of harmful free radicals that damage cell membranes, proteins, lipids and DNA, and have been linked to certain diseases and skin aging. Luckily our bodies have methods to help control these harmful free radicals, such as antioxidant and detoxification enzymes.
However, common genetic changes in the GPX1 and NQO1 genes reduce the efficiency of two important enzymes required for proper oxidation protection. These genetic variants have been linked to increased signs of skin aging.
Wrinkles are the most obvious sign of skin aging and they generally form due to changes over time that reduce skin flexibility and the skins ability to protect itself from damage. Tissue breakdown and synthesis are part of normal physiological processes, but as we age, the balance tips and new tissue is not synthesized fast enough, contributing to wrinkle formation.
Several environmental factors also contribute to wrinkles, including smoking, alcohol and sunlight. Matrix metalloproteinases (MMPs) are enzymes that degrade tissues, as part of the tissue breakdown process. Recent studies have shown an association between specific MMP1 and MMP3 variants and increased wrinkle development. UV radiation also increases MMP-1 and MMP-3 expression, partly explaining the link between excessive sun exposure and wrinkles.